Minimal Inhibitory Concentration (MIC)

Minimal Inhibitory Concentration (MIC) is one of the many antimicrobial and disinfectant testing services offered by Nova Biologicals, Inc.

The Minimal Inhibitory Concentration (MIC) of each selected antibiotic/antimicrobial is determined by utilizing serial dilutions of the antibiotic/antimicrobial which has been inoculated with the organisms listed above and incubated. The minimal inhibitory concentration (MIC) is the lowest concentration without apparent growth.

MIC determinations are conducted according to M07-A9 – Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard – Eighth Edition & Performance Standards for Antimicrobial Susceptibility Testing and M11-A8 – Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Anaerobically; Approved Standard – Seventh Edition. Clinical Laboratory Standards Institute (formerly NCCLS).

The Minimum Bactericidal Concentration (MBC) is determined using microtiter plate well of antibiotic inoculated with a known concentration of the isolated infecting organism. After overnight incubation and subsequent quantitative subculture of the non-turbid wells, the concentration of drug that produces a 99.9% reduction in the starting inoculum determines the MBC.

MBC determinations are conducted according to M07-A6 – Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard – Sixth Edition. Clinical Laboratory Standards Institute (formerly NCCLS).

For more information regarding MIC and MBC testing contact us.

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